PIR Antibody, Biotin conjugated

Datasheet

Code	CSB-PA018032LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PIR Polyclonal antibody

Uniprot No.

O00625

Target Names

PIR

Alternative Names

3-dioxygenase PIR antibody; Iron binding nuclear protein antibody; Pir antibody; PIR_HUMAN antibody; Pirin antibody; Probable quercetin 2 antibody; probable quercetin 2,3-dioxygenase PIR antibody; Probable quercetinase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pirin protein (1-290AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).

Gene References into Functions

Data suggest that only the Fe(III) form of pirin [not the Fe(II) form] enhances affinity of binding between p65 and DNA in the pirin-p65-DNA supramolecular complex. (pirin = quercetin 2,3-dioxygenase; p65 = RELA proto-oncogene NF-kappaB subunit) PMID: 28825294
Pirin regulates E-cadherin independently of Bcl3-Slug signaling. PMID: 25680527
The NRF2 transcription factor binds to this element in vivo and drives the basal PIR expression. PMID: 24390086
Pirin is a newly identified binding partner of EAF2/U19 capable of down-regulating EAF2/U19 protein and alleviating its inhibition of prostate cancer cell survival/proliferation. PMID: 24272884
Data indicate that the R-shaped area composes the interface for pirin-NF-kappaB binding that is responsible for modulation of NF-kappaB's DNA-binding properties. PMID: 23716661
pirin may have a relevant role in melanoma progression. PMID: 21514450
knockdown of pirin or treatment with the small molecule inhibited melanoma cell migration PMID: 20711196
This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on bone mineral density and osteoporotic risk. PMID: 19766747
An abnormal pattern of PIR sub-cellular localization is a characteristic feature of a subset of melanomas, and suggest it may represent a marker associated with disease progression. PMID: 20089166
Pirin downregulation is a feature of acute myeloid leukemia and leads to impairment of terminal myeloid differentiation. PMID: 20010624
x-ray crystallography of of human pirin shows that it is an iron-binding nuclear protein and transcription cofactor PMID: 14573596
First report of enzymatic activity for any member of the Pirin family which may be an important connection to their roles in transcriptional regulation. PMID: 15951572

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Pirin family

Tissue Specificity

Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.

Database Links

HGNC: 30048

OMIM: 300931

KEGG: hsa:8544

STRING: 9606.ENSP00000369785

UniGene: Hs.495728

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